Enhanced social distancing restrictions covering Burnley and Hyndburn will be lifted from Wednesday 2 September.
This brings the boroughs in line with the rest of the country, though residents have been warned not to be complacent about the coronavirus pandemic.
Dr Sakthi Karunanithi, Lancashire's director of public health, said: "In both Burnley and Hyndburn infection rates are significantly above the national average with an increasing rate in Hyndburn. Coronavirus does not respect administrative boundaries and there is a high volume of social, educational and commuting travel between these areas and Lancashire's hotspots.
"The virus is very much still present in both Burnley and Hyndburn so residents must play their part to help protect themselves, their families and their communities."
Elsewhere in the county, all existing restrictions remain, which means that in Preston and parts of Pendle residents can't have visitors or visit others in their homes or gardens, or socialise with friends at indoor venues. They can continue to meet in groups of up to six in outdoor public areas.
Residents in other parts of Pendle and in the northern part of Blackburn with Darwen have additional restrictions which means they cannot socialise with anyone, anywhere indoors or outdoors.
Gary Hall, deputy chair of the Lancashire Resilience Forum which is leading the county's response to the coronavirus pandemic, said: "In most parts of Lancashire things are heading in the right direction, and I would like to thank everyone for playing their part. I understand how difficult it has been and appreciate the sacrifice people have made.
"If we continue on this path I am hopeful that all parts of Lancashire will have the remaining restrictions lifted soon, but this depends on people following the rules wherever they live in the county, and continuing to practice social distancing, washing hands regularly, wearing a face covering when they should and following the guidance given to them if contacted by NHS Test and Trace."
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